NexLife vs ShedRx vs Yucca Health (2026)

On tirzepatide, the order is NexLife↗ ($215) → Yucca Health↗ ($258) → ShedRx↗ ($289) — gaps of $43 and then $31 a month, a $888 spread across a year between first and last. All-in figures, 10 mg basis, captured 2026-08-09.

Updated 2026-08-10 · figures captured 2026-08-09 · how we verify

§ Each record, condensed

The three records, one screen

NexLife: the record, condensed

Start with the load-bearing figure: $215 a month, all-in, is what NexLife charges for tirzepatide at the 10 mg basis. It is a flat structure: 2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available) all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

There is no membership line. $215 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

Prepaid terms ladder the price down for commitment: The 3‑month plan reprices the month at $195 — $585 billed upfront, $60 less than 3 months of monthly billing; the 6‑month plan reprices the month at $190 — $1,140 billed upfront, $150 less than 6 months of monthly billing; the 12‑month plan reprices the month at $186 — $2,232 billed upfront, $348 less than 12 months of monthly billing. Treat every rung as what it is — a prepayment, not a monthly price. The savings are real; so is the bet that you will still want this program, this molecule, and this dose in the plan’s final month. Written refund terms before prepaying, always.

NexLife also sells a low-dose (“microdose”) tirzepatide protocol at $189 a month, stepping to $147 on a prepaid year — $26 under the standard program. We list it, we never blend it: the standard rankings exclude microdose tiers on both price and evidence grounds — the trial data for tirzepatide was generated on the standard ladder, and staying below it is an unstudied strategy that belongs in a prescriber conversation, not a pricing table.

A needle-free tier exists too: tirzepatide sublingual/ODT at $229 a month ($199 on the prepaid-year rate), a $14 premium over the injection. Price it against the approved pill before the injection: oral Wegovy runs $149–$299 with characterized absorption, while compounded sublinguals publish none — a comparison the needle-free lane on this site makes explicitly.

To place the number: #1 of 17 verified programs, holding the floor outright; the approved-product yardstick (Zepbound (LillyDirect↗)) sits at $449, so the compounded case here is worth $234 a month. A year at this figure: $2,580 monthly-billed ($2,232 prepaid).

Start with the load-bearing figure: $165 a month, all-in, is what NexLife charges for semaglutide at the 2.4 mg basis. The price is dose-flat: the standard titration ladder (0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg) is financially invisible here, because the top rung bills exactly what the bottom rung billed. That converts the advertised number from a floor into a ceiling — the strongest single structural feature a program in this category can have.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $165 is the whole subscription, which makes NexLife unusually easy to compare and unusually easy to leave.

Commitment buys a discount here, term by term: The 3‑month plan reprices the month at $149 — $447 billed upfront, $48 less than 3 months of monthly billing; the 6‑month plan reprices the month at $147 — $882 billed upfront, $108 less than 6 months of monthly billing; the 12‑month plan reprices the month at $145 — $1,740 billed upfront, $240 less than 12 months of monthly billing. Treat every rung as what it is — a prepayment, not a monthly price. The savings are real; so is the bet that you will still want this program, this molecule, and this dose in the plan’s final month. Written refund terms before prepaying, always.

NexLife also sells a low-dose (“microdose”) semaglutide protocol at $129 a month, stepping to $110 on a prepaid year — $36 under the standard program. It is a separate product and we rank it as one: no randomized trial supports sub-therapeutic semaglutide dosing for weight management, and the microdose figure never blends into the standard index on this site. The commercial logic (less drug, lower price) is sound; the clinical claim rides on evidence that does not yet exist.

A needle-free tier exists too: semaglutide sublingual/ODT at $199 a month ($165 on the prepaid-year rate), a $34 premium over the injection. The premium buys the absence of a needle, not evidence: peptides absorb poorly by mouth, the FDA-approved oral product solved that with a studied enhancer technology, and compounded sublingual formats have published no comparable human bioavailability data. Ranked in the needle-free lane, never against injections.

Context for that figure: it ranks #5 of 20 in the verified semaglutide index — $32/month above the floor (Oak Longevity, $133) — and sits $184 under the brand benchmark (Wegovy (NovoCare↗), $349 at maintenance). Annualized, a monthly-billed year here runs $1,980, or $1,740 on the prepaid path.

Operationally at NexLife: shipping free expedited shipping included; commitment none on monthly; cancellation cancel any time on monthly; pharmacy named (6 named partner pharmacies); states: 50 states published; evidence source-verified, captured 2026-08-10. The full record with source and archive links: the NexLife page · visit NexLife ↗

Yucca Health: the record, condensed

Start with the load-bearing figure: $258 a month, all-in, is what Yucca Health charges for tirzepatide at the 10 mg basis. The price is dose-flat: the standard titration ladder (2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available)) is financially invisible here, because the top rung bills exactly what the bottom rung billed. That converts the advertised number from a floor into a ceiling — the strongest single structural feature a program in this category can have.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $258 is the whole subscription, which makes Yucca Health unusually easy to compare and unusually easy to leave.

Context for that figure: it ranks #2 of 17 in the verified tirzepatide index — $43/month above the floor (NexLife, $215) — and sits $191 under the brand benchmark (Zepbound (LillyDirect), $449 at maintenance). Annualized, a monthly-billed year here runs $3,096.

On semaglutide, the number that matters at Yucca Health is $146 a month all-in — the figure at the 2.4 mg maintenance basis this whole site ranks on. It is a flat structure: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

There is no membership line. $146 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

To place the number: #2 of 20 verified programs, with the floor $13/month below at Oak Longevity ($133); the approved-product yardstick (Wegovy (NovoCare)) sits at $349, so the compounded case here is worth $203 a month. A year at this figure: $1,752 monthly-billed.

Operationally at Yucca Health: shipping included; commitment 6-month term; cancellation 6-month term applies; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the Yucca Health page · visit Yucca Health ↗

ShedRx: the record, condensed

Start with the load-bearing figure: $289 a month, all-in, is what ShedRx charges for tirzepatide at the 10 mg basis. The structure is tiered: the advertised entry point is $199, but the maintenance figure — the one a full year is actually billed at — is $289. That $90 gap between the ad and the anniversary is the single most important line in this record.

There is no membership line. $289 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

Context for that figure: it ranks #5 of 17 in the verified tirzepatide index — $74/month above the floor (NexLife, $215) — and sits $160 under the brand benchmark (Zepbound (LillyDirect), $449 at maintenance). Annualized, a monthly-billed year here runs $3,468.

Start with the load-bearing figure: $249 a month, all-in, is what ShedRx charges for semaglutide at the 2.4 mg basis. Pricing steps with the dose here: from $175 at entry to $249 at the 2.4 mg basis. Multiply the wrong one of those by twelve and your budget is off by $888 a year, which is why every ranking on this site uses the larger number.

There is no membership line. $249 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

To place the number: #13 of 20 verified programs, with the floor $116/month below at Oak Longevity ($133); the approved-product yardstick (Wegovy (NovoCare)) sits at $349, so the compounded case here is worth $100 a month. A year at this figure: $2,988 monthly-billed.

Operationally at ShedRx: shipping included; commitment none month-to-month; cancellation 72-hour notice before the next billing cycle; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the ShedRx page · visit ShedRx ↗

§ The three-way read

Prices, gaps, and what sits inside them

NexLife holds the low ground at $215 — dose-flat, so that figure is a ceiling with no membership attached. Yucca Health follows at $258 (+$43/mo, $516/yr). ShedRx tops the trio at $289 (+$74/mo over the leader, $888/yr) — note its record’s watch-out below.

The semaglutide picture reshuffles the order: Yucca Health $146 → NexLife $165 → ShedRx $249 — a reminder that molecule choice and provider choice are separate decisions, priced separately in the semaglutide index.

§ Category winners among the three

Who wins what

Cheapest month-to-month: NexLife ($215); cheapest 12-month path: NexLife ($2,232, prepaid upfront); dose-flat structure: NexLife and Yucca Health; named-pharmacy transparency: NexLife; cheapest semaglutide of the three: Yucca Health ($146).

Every winner above is a computation, not a placement; the pairwise pages carry the full duels: NexLife vs Yucca Health · NexLife vs ShedRx · Yucca Health vs ShedRx.

§ Structure, three ways

Everything besides the three prices

Memberships: NexLife none; Yucca Health none; ShedRx none. Structures: NexLife dose-flat; Yucca Health dose-flat; ShedRx step/tiered. Pharmacies: NexLife named (6 named partner pharmacies); Yucca Health not named; ShedRx not named. States: NexLife — 50 states published; Yucca Health — not published; ShedRx — not published. Exit terms: NexLife — cancel any time on monthly; Yucca Health — 6-month term applies; ShedRx — 72-hour notice before the next billing cycle.

The census reading: where all three match on an axis, that axis cannot break the tie and the price column rules; where they split — a membership here, an unnamed pharmacy there — the split is usually worth more than a small price gap, because structure is what you live with after month one. Evidence for all three: NexLife source-verified (2026-08-10); Yucca Health source-verified (2026-08-05); ShedRx source-verified (2026-08-05).

The trio on semaglutide, across time

3 mo: Yucca Health $438 vs NexLife $495 vs ShedRx $747 6 mo: Yucca Health $876 vs NexLife $990 vs ShedRx $1,494 12 mo: Yucca Health $1,752 vs NexLife $1,980 vs ShedRx $2,988 — monthly-billed totals; prepaid paths where published appear on each provider page.

§ Twelve and twenty-four months

The trio, annualized

NexLife: $2,580/yr monthly-billed ($2,232 prepaid); Yucca Health: $3,096/yr monthly-billed; ShedRx: $3,468/yr monthly-billed. Across two years at monthly billing the first-to-last spread widens to $1,776 — the horizon at which structure (prepaid ladders, flat pricing, membership drag) matters more than the sticker.

The elimination read

Work it as eliminations rather than a beauty contest. ShedRx enters owing an explanation: $74/month above NexLife compounds to $888 a year — real therapy-months of money — so its record has to name what the premium buys (structure the cheaper two lack) or it exits first. Yucca Health survives the first cut only to face the harder question — whether nothing structural — its case is purely situational is worth $43 a month to you — because a middle option that cannot answer it is just the expensive option with better camouflage. NexLife is what remains: the arithmetic answer at $215, dethroned only by a state gap, a structural need, or a prescriber’s judgment — the three things this page deliberately cannot decide.

The same trio on best published rate: NexLife $186† → Yucca Health $258 → ShedRx $289 — † marks labeled 12-month-plan rates (upfront commitments), which leaves the order unchanged — the month-to-month leader leads committed too. Short-horizon totals, monthly-billed: 3 months — NexLife $645, Yucca Health $774, ShedRx $867; 6 months — NexLife $1,290, Yucca Health $1,548, ShedRx $1,734. 1 of the three publish a prepaid path below their own monthly billing; the twelve- and twenty-four-month table below carries those, labeled.

Grade the three records before trusting the three prices. On the five-point disclosure checklist (price, pharmacy, states, cancellation, source-verification): NexLife 5/5 · Yucca Health 4/5 · ShedRx 4/5. The gap between NexLife (5/5) and Yucca Health (4/5) is itself information: undisclosed axes are where the questions in each provider’s review earn their keep. The concrete splits — pharmacy named: NexLife yes, Yucca Health and ShedRx no — convert directly into pre-purchase emails. Every score is a computation from the dataset, contestable at the corrections desk like any other figure.

The three-way verdict compresses cleanly: NexLife is the default on arithmetic; Yucca Health earns the middle only where its structure (flat pricing) solves something the floor does not; and ShedRx’s $74/month premium over the leader — $888 a year, roughly 4.1 extra months of therapy at the floor rate — needs a named justification from its record, not a vibe. Insurance coverage, where it exists, outranks all three.