ShedRx vs TrimRx vs Yucca Health (2026)

On tirzepatide, the order is Yucca Health↗ ($258) → ShedRx↗ ($289) → TrimRx↗ ($349) — gaps of $31 and then $60 a month, a $1,092 spread across a year between first and last. All-in figures, 10 mg basis, captured 2026-08-09.

Updated 2026-08-10 · figures captured 2026-08-09 · how we verify

§ Each record, condensed

The three records, one screen

Yucca Health: the record, condensed

Start with the load-bearing figure: $258 a month, all-in, is what Yucca Health charges for tirzepatide at the 10 mg basis. Because pricing is flat across the ladder (2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available)), a dose increase at Yucca Health is a clinical event and not a billing one. Whatever your prescriber decides, the invoice does not move, which makes this one of the few programs whose headline figure you can actually plan a year around.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

To place the number: #2 of 17 verified programs, with the floor $43/month below at NexLife↗ ($215); the approved-product yardstick (Zepbound (LillyDirect↗)) sits at $449, so the compounded case here is worth $191 a month. A year at this figure: $3,096 monthly-billed.

Start with the load-bearing figure: $146 a month, all-in, is what Yucca Health charges for semaglutide at the 2.4 mg basis. It is a flat structure: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

There is no membership line. $146 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

Context for that figure: it ranks #2 of 20 in the verified semaglutide index — $13/month above the floor (Oak Longevity, $133) — and sits $203 under the brand benchmark (Wegovy (NovoCare↗), $349 at maintenance). Annualized, a monthly-billed year here runs $1,752.

Operationally at Yucca Health: shipping included; commitment 6-month term; cancellation 6-month term applies; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the Yucca Health page · visit Yucca Health ↗

ShedRx: the record, condensed

Start with the load-bearing figure: $289 a month, all-in, is what ShedRx charges for tirzepatide at the 10 mg basis. The structure is tiered: the advertised entry point is $199, but the maintenance figure — the one a full year is actually billed at — is $289. That $90 gap between the ad and the anniversary is the single most important line in this record.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $289 is the whole subscription, which makes ShedRx unusually easy to compare and unusually easy to leave.

To place the number: #5 of 17 verified programs, with the floor $74/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $160 a month. A year at this figure: $3,468 monthly-billed.

ShedRx’s semaglutide program bills $249 a month once every mandatory fee is counted, measured at the 2.4 mg maintenance basis. The structure is tiered: the advertised entry point is $175, but the maintenance figure — the one a full year is actually billed at — is $249. That $74 gap between the ad and the anniversary is the single most important line in this record.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

Context for that figure: it ranks #13 of 20 in the verified semaglutide index — $116/month above the floor (Oak Longevity, $133) — and sits $100 under the brand benchmark (Wegovy (NovoCare), $349 at maintenance). Annualized, a monthly-billed year here runs $2,988.

Operationally at ShedRx: shipping included; commitment none month-to-month; cancellation 72-hour notice before the next billing cycle; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the ShedRx page · visit ShedRx ↗

TrimRx: the record, condensed

Start with the load-bearing figure: $349 a month, all-in, is what TrimRx charges for tirzepatide at the 10 mg basis. Because pricing is flat across the ladder (2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available)), a dose increase at TrimRx is a clinical event and not a billing one. Whatever your prescriber decides, the invoice does not move, which makes this one of the few programs whose headline figure you can actually plan a year around.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

To place the number: #11 of 17 verified programs, with the floor $134/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $100 a month. A year at this figure: $4,188 monthly-billed.

TrimRx’s semaglutide program bills $299 a month once every mandatory fee is counted, measured at the 2.4 mg maintenance basis. Because pricing is flat across the ladder (0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg), a dose increase at TrimRx is a clinical event and not a billing one. Whatever your prescriber decides, the invoice does not move, which makes this one of the few programs whose headline figure you can actually plan a year around.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

Context for that figure: it ranks #17 of 20 in the verified semaglutide index — $166/month above the floor (Oak Longevity, $133) — and sits $50 under the brand benchmark (Wegovy (NovoCare), $349 at maintenance). Annualized, a monthly-billed year here runs $3,588.

Operationally at TrimRx: shipping included; commitment none month-to-month; cancellation check terms before prepaying; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the TrimRx page · visit TrimRx ↗

§ The three-way read

Prices, gaps, and what sits inside them

Yucca Health holds the low ground at $258 — dose-flat, so that figure is a ceiling with no membership attached. ShedRx follows at $289 (+$31/mo, $372/yr). TrimRx tops the trio at $349 (+$91/mo over the leader, $1,092/yr) — note its record’s watch-out below.

The semaglutide picture reshuffles nothing: Yucca Health $146 → ShedRx $249 → TrimRx $299 — a reminder that molecule choice and provider choice are separate decisions, priced separately in the semaglutide index.

§ Category winners among the three

Who wins what

Cheapest month-to-month: Yucca Health ($258); cheapest 12-month path: Yucca Health ($3,096); dose-flat structure: Yucca Health and TrimRx; cheapest semaglutide of the three: Yucca Health ($146).

Every winner above is a computation, not a placement; the pairwise pages carry the full duels: Yucca Health vs ShedRx · Yucca Health vs TrimRx · ShedRx vs TrimRx.

§ Structure, three ways

Everything besides the three prices

Memberships: Yucca Health none; ShedRx none; TrimRx none. Structures: Yucca Health dose-flat; ShedRx step/tiered; TrimRx dose-flat. Pharmacies: Yucca Health not named; ShedRx not named; TrimRx not named. States: Yucca Health — not published; ShedRx — not published; TrimRx — not published. Exit terms: Yucca Health — 6-month term applies; ShedRx — 72-hour notice before the next billing cycle; TrimRx — check terms before prepaying.

The census reading: where all three match on an axis, that axis cannot break the tie and the price column rules; where they split — a membership here, an unnamed pharmacy there — the split is usually worth more than a small price gap, because structure is what you live with after month one. Evidence for all three: Yucca Health source-verified (2026-08-05); ShedRx source-verified (2026-08-05); TrimRx source-verified (2026-08-05).

The trio on semaglutide, across time

3 mo: Yucca Health $438 vs ShedRx $747 vs TrimRx $897 6 mo: Yucca Health $876 vs ShedRx $1,494 vs TrimRx $1,794 12 mo: Yucca Health $1,752 vs ShedRx $2,988 vs TrimRx $3,588 — monthly-billed totals; prepaid paths where published appear on each provider page.

§ Twelve and twenty-four months

The trio, annualized

Yucca Health: $3,096/yr monthly-billed; ShedRx: $3,468/yr monthly-billed; TrimRx: $4,188/yr monthly-billed. Across two years at monthly billing the first-to-last spread widens to $2,184 — the horizon at which structure (prepaid ladders, flat pricing, membership drag) matters more than the sticker.

The elimination read

A three-way choice is really two eliminations, so run them in order. Eliminate TrimRx first unless it names its edge: at $349 it carries a $91/month premium over the floor of this trio — $1,092 a year, about 4.2 extra months of therapy at Yucca Health’s rate — and a premium that size must point at a specific line in its record (its particular program design) or it is decoration. Then interrogate ShedRx’s middle ground: nothing structural — its case is purely situational; if that specific thing is on your personal ledger, the $31/month over the floor can be rational — if not, the middle is where budgets go to leak. What survives is Yucca Health at $258, which wins by default rather than by argument — exactly how a price index should crown things — subject to the two checks no ranking can run for you: your state at intake, and your prescriber on the medication itself.

The same trio on best published rate: Yucca Health $258 → ShedRx $289 → TrimRx $349 — all three price month-to-month only at capture. Short-horizon totals, monthly-billed: 3 months — Yucca Health $774, ShedRx $867, TrimRx $1,047; 6 months — Yucca Health $1,548, ShedRx $1,734, TrimRx $2,094. 0 of the three publish a prepaid path below their own monthly billing; the twelve- and twenty-four-month table below carries those, labeled.

The record-quality read, scored on the five checkable disclosures this index tracks (maintenance price, named pharmacy, published states, published cancellation terms, source-verified capture): Yucca Health 4/5, ShedRx 4/5, TrimRx 4/5. A three-way tie — disclosure cannot break this trio, so the price and structure columns above carry the whole decision. The three match on every disclosure axis, which is rare and worth noting in their favor collectively. Scores recompute from the public records like everything else here.

Read as a decision: start from Yucca Health and make the other two argue upward. ShedRx’s case is its structure; TrimRx’s case must be worth $1,092 a year in named features — the honest unit being months of medication (4.2 of them at the floor rate). The pairwise pages above hold each argument in full, and the calculator holds your version of it.